A while back I mentioned we were waiting on some test results of the tissue taken from the D&C I had after our second miscarriage (known as “products of conception” or “POC” testing).
We had a phone call from our OB last weekend confirming what we had already suspected – that this pregnancy loss was also due to a chromosomal abnormality.
But what was interesting, and what we weren’t excepting, was that this test showed exactly the same result as the testing of our first fetus – part of Chromosome 1 was missing again.
So, this is where it gets interesting.
It’s difficult to assume at this stage that both miscarriages were simply “chance events”.
Our OB has explained to us that he now has a suspicion that one of us may have a tiny piece missing from one of our chromosomes (specifically, chromosome 1) that we have been passing on to our fetus’ (as a quick run down, when an embryo develops it has 23 pairs of chromosomes, with 1 part of each pair taken from each parent, to make up 46 chromosomes in total).
So, if he is right, it means that for chromosome 1, there are potentially 4 combinations of pairs that could be made each time we conceive (two where the embryo does not inherit the dodgy gene and two where the embryo does inherit it).
Which basically means there could be a 50% chance of miscarriage each time (or, based on our assumptions, if we are super unlucky and both of us has a dodgy chromosome, we have a 1 in 4 chance of a successful full term pregnancy each time).
Given this suspicion, we have both been sent off for more testing to confirm whether this is actually the case (we have both had 2 lots of chromosome screens already and they have both been clear each time, so we are now having a more in-depth analysis done on this specific chromosome).
Our OB gave us a quick overview of potential options – essentially, we can keep “rolling the dice” and hoping not to pass on that specific chromosome each time, or we can explore the option of IVF (where each embryo can be screened for defects) and hopefully reduce the likelihood of miscarriage in each case.
Since it’s still fairly early days for us, we’re both happy (well, as happy as you can be in such a situation) to keep “rolling the dice” for the time being – we both feel as though we’re prepared to keep going through this process with the knowledge that there is half a chance we could have a miscarriage on each occasion (on the bright side, there is also half a chance that we could have a successful full term pregnancy each time!)
We’re assuming that, since it’s only a matter of chance, the gamble should pay off eventually, right!?
But in saying that, we will still take the next lot of chromosomal screening tests just for confirmation (or at the very least, further information about what we’re in for).
Until next time…
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